Subsite Awareness in Neuropathology Evaluation of National Toxicology Program (NTP) Studies
نویسندگان
چکیده
منابع مشابه
Hormesis at the National Toxicology Program (NTP): Evidence of Hormetic Dose Responses in NTP Dose-Range Studies.
The National Toxicology Program (NTP) dose-ranging studies typically employ five dosages and a concurrent control and are conducted for 2- and 13-week exposure periods. Because five doses are employed it suggested the possibilities of the occurrence of sub-NOAEL doses in many of these bioassays and of evaluating the occurrence of hormesis within the NTP bioassay. As a result, 59 environmentally...
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The NTP is evaluating several lines of genetically altered mice for possible use in identifying and assessing carcinogens. The NIEHS/NTP programs and progress in this area were recently reviewed by the NTP Board of Scientific Counselors (BSC). A number of comments and concerns were raised. This commentary summarizes and responds to the BSC review and offers some thoughts on future directions fo...
متن کاملStatistical studies in genetic toxicology: a perspective from the U.S. National Toxicology Program.
This paper surveys recent, as yet unpublished, statistical studies arising from research in genetic toxicology within the U.S. National Toxicology Program (NTP). These studies all involve analyses of data from Ames Salmonella/microsome mutagenicity tests, but the statistical methodologies are broadly applicable. Three issues are addressed: First, what is a tenable sampling model for Ames test d...
متن کاملToxicokinetics in the National Toxicology Program.
Toxic responses to test chemicals are known to be dependent on the exposure route, the kinetic behavior of the chemical, and the dose used in the toxicology study. Therefore, knowledge of internal dose is indispensable for the interpretation of toxicology study results, for the facilitation of interspecies scaling, and for risk assessment. By monitoring the blood and/or tissue concentrations of...
متن کاملNominations NATIONAL TOXICOLOGY PROGRAM CHEMICAL TESTING
The UAW believes that NTP should explore additional options for testing of chemicals beyond inclusion on this test list, and for funding this testing while using NTP protocols. In particularly, the UAW urges NTP to explore with EPA the use of authority under the Toxic Substances Control Act to promulgate test rules to compel producers of chemicals to provide funding for bioassays. In addition, ...
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ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 2013
ISSN: 0192-6233,1533-1601
DOI: 10.1177/0192623313501893